The program on genomics and nutrition is an interdisciplinary program that aims to educate a new generation of epidemiologists capable of linking "sick molecules" to "sick populations" by applying advanced genomic, molecular, and quantitative methods to the study of disease distributions in human populations, and to the assessment of gene-gene and gene-environment interactions for disease causation. The overarching objective of this field is to integrate the research and teaching activities of faculty members involved in public health genomics and nutrition, and to foster further development in these academic activities so that prevention of diseases is possible with improved understanding of the issues related to "sick molecules" to "sick populations.
A cooperative of UCLA faculty who carry out basic and applied research and training in demography. CCPR comprises over 70 active faculty researchers from the disciplines of anthropology, economics, epidemiology, geography, human resources & organizational behavior, law, medicine (pediatrics and psychiatry), population, psychology, community health services, public policy, social welfare, sociology, and urban planning. CCPR researchers span several schools---including the College of Letters and Sciences, the School of Public Health, the School of Medicine, and the School of Public Affairs---and multiple academic departments within UCLA.
The MBI is an interdepartmental organized research unit within the Life Sciences Division of the College of Letters & Sciences. It is designed to bring together UCLA researchers in the now broad area of molecular biology.
UCLA Clinical Microarray Core (CMC) is located at the Immunogenetics Center with approximately 900 square feet of laboratory space, operated by four experienced genomic scientists (http://www.pathology.ucla.edu/cmc.html). The CMC houses Affymetrix GeneChip® System 3000Dx v.2 for clinical microarray applications (GeneChip® Scanner 3000Dx v.2, two GeneChip® Fluidics Station 450Dx v.2, GeneChip Hybridization Oven 645, and Workstation with Affymetrix Molecular Diagnostics Software), Affymetrix GeneChip® Instrument Systems for research microarray applications (GeneChip® Scanner 3000 7G, two GeneChip® Fluidics Station 450, GeneChip Hybridization Oven 640, and Workstation with Affymetrix Command Console software), Beckman Coulter ArrayPlex for fully automated microarray target preparation, MagNa Pure Compact Instrument for fast and easy automated isolation of nucleic acids, and MagNa Lyzer instrument for automated tissue homogenization. Agilent 2100 Bioanalyzer and NanoDrop 8000 for RNA/DNA quality control, DNA Engine Tetrad 2 Thermal Cycler, and other bioinformatics infrastructures.
With the well-integrated instruments, the CMC has the capacity to provide a wide range of clinical diagnosis, clinical trials, and translational services in a high-throughput and timely manner. Our clinical services include differential gene expression assay, gene alternative splicing assay, and copy number variation assay. Our translational research services include gene array hybridization, SNP genotyping, tiling array hybridization, exon array hybridization, and chip-chip hybridization at a capacity of 120 samples/week. By providing the above services, The CMC has supported a wide range of investigations, including 1) evaluation of drug effect 2) optimization of drug dose 3) identification of drug targets 4) identification of expression signature for disease classification 5) identification of gene expression markers for disease diagnosis/prognosis 6) evaluation of host response to pathogen infection 7) identification of disease-associated SNPs 8) identification of pathogenic copy number variations 9) understanding molecular mechanisms of pathogenesis and evolution.
In addition to offering wet-lab services, the CMC has developed a broad bioinformatics infrastructure and an efficient means for data acquisition, storage and analysis. We access various advanced software including GeneSpring 9.0, Partek Genomics Suite, D-chip, SAM, and Ingenuity Pathway Analysis. This well-established data management, data analysis and data integration systems have significantly enhanced the overall capacity of the CMC to rapidly digest and transform the large quantity of data into novel findings.
Students participate in many of the activities of other biomedical science doctoral programs at UCLA. Areas of particular strength include chemical carcinogenesis, repair of DNA damage, air pollution toxicology, nanotoxicology, and the environmental causation of Parkinson's disease.
The GATP program offers support for students interested in conducting genomic research. Its program directors are Dr. Ken Lange and Dr. Janet Sinsheimer, both faculty in the BWF-IT-MD program.
This training program for physician-scientists offers the opportunity to combine clinical fellowship training with advanced research training to complete a graduate degree.
ACCESS is an umbrella graduate program that represents 12 Ph.D. programs to maximize student choice by providing them with a range of research opportunities that span molecular, cellular, and integrative areas of the biosciences.